Improvement of Myocardial Structure after Developed Fibrous Degeneration Under the Use of Allogenic Biomaterial

Introduction. The question of the possibility recovery postischemic myocardium remains relevant. Aim. aim study was to effect dispersed decellularized allogeneic extracellular matrix (allogeneic biomaterial, DAB) on developed fibrous degeneration myocardium, as well reveal possible mechanisms cellular regeneration. Materials and methods. muscular wall heart rats subjected cryodestruction. After 45 days, main group were intramyocardially injected with a suspension biomaterialinto area affected control saline. Results discussions. In experimental group, there regression formed connective tissue, chemoattraction progenitor cells, their differentiation integration into myocardium. thickness part left ventricle three orders magnitude higher than in group. Conclusion. Analysis results indicates that adult mammals has powerful regenerative reserve. It is likely that, based use DAB, protocol can be allows restoration muscle even conditions already degeneration.